General SummaryOrum Therapeutics is seeking to expand our in-house analytical capabilities to help advance quality compounds toward the clinic. The successful candidate will have a strong background in LC-MS antibody/protein characterization or bioanalytical quantitation and a passion for driving high-impact projects in the anti-cancer drug discovery space. The candidate will conduct bench-based research focused on sample preparation, LC-MS and HPLC analytical characterization/quantitation for ADC, Antibody, small molecule drug, data analysis and report within a dynamic, enthusiastic, highly interdisciplinary and collaborative team.Principle Duties and Responsibilities
- Perform routine lab experiments to support various projects analytical needs and bioconjugation workflow, including instrument operation, maintenance and troubleshooting (Thermo Vanquish UHPLC-Orbitrap MS, Waters Acquity UPLC-SQD MS, and Agilent HPLC and UV-Vis).
- Perform QC and characterization of ADC, antibodies, and small molecules using appropriate analytical methods including intact mass analysis, de-glycosylation and reduction LC-MS, DAR measurement, HPLC methodology (SEC, HIC, IEX, RP etc), peptide mapping, PTM profiling, native MS, structural characterization for small molecule drugs.
- Prepare and analyze samples from various sources, such as purified protein products, biological matrix (plasma, serum and tissues, etc).
- Identify metabolites of ADC from in- vivo or in-vitro samples using appropriate sample handling and analytical methods such as affinity capture, forced release, MS/MS, SIM-MS, etc.
- Optimize analytical methods and provide technical guidance to troubleshoot, investigate, and resolve technical issues related to method implementations.
- Proactively recommend and evaluate instrumentation that expands internal analytical capabilities.
- Present written and oral reports to multidisciplinary team.
- Enter all data into electronic laboratory notebooks and database daily, generate weekly summary reports for management review.
- Contribute to the build-out and upkeep of an expanding laboratory through maintaining shared equipment, assisting with general laboratory housekeeping, and developing processes for improving workflow efficiency.
Skills, Abilities & Competencies
- Experience in the biopharmaceutical industry.
- Track record of accomplishment in the field, as indicated by publications in peer reviewed journals.
- General knowledge of analytical instrumentation including operational, maintenance, and design aspects.
- Hands-on experience, including antibody drug conjugate sample handling, preparation (de-glycosylation, reduction, and in-solution/in-gel digestion), and characterization (HPLC (SEC, HIC, IEX, RP etc), LC-MS, Uv-Vis), basic instrument maintenance and troubleshooting.
- An active scientific curiosity and interest for complementary disciplines within the pharmaceutical industry.
- Passionate about improving technological solutions using new and emerging technologies.
- Demonstrated problem solving, attention to detail and result oriented behaviors in a fast-paced environment.
- Excellent verbal and written communication skills, creativity, and strong interpersonal skills.
- Enthusiasm for collaborating with multidisciplinary teams of chemists, protein engineers, and biologists.
- Strong communication and time-management skills, the ability to handle multiple projects simultaneously, and the ability to effectively collaborate with a global multidisciplinary team.
- Strong work ethic and ability to work independently with minimal supervision.
Education- Ph.D. or equivalent degree in Analytical chemistry or a related field with minimum 5 years' experience, MS degree with 8 years', or BS degree with 11 years'.Orum offers a Core benefits program which includes: medical, dental, short and long term disability, life insurance and a 401k.*U.S. citizens and those authorized to work in the U.S. (green card) are encouraged to apply. We are unable to sponsor at this time.*Candidate must be able to pass a background investigation.*Unable to work with 3rd party candidates or agencies.To perform this job successfully, an individual must be able to perform each essential duty satisfactorily within the context of the representative work environment and physical demands described above. Likewise, qualifications listed are representative of the knowledge, skills, and abilities required to perform the position's essential functions. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.Orum Therapeutics is an Equal Opportunity Employer (EOE).