Associate Principal Scientist, Safety PharmacologyApply remote type Not Applicable locations USA - Pennsylvania - West Point time type Full time posted on Posted Yesterday time left to apply End Date: December 11, 2024 (13 days left to apply) job requisition id R324115Job DescriptionThe Nonclinical Drug Safety (NDS) division at our company is seeking a motivated and talented in vitro pharmacologist/physiologist with experience in cardiovascular de-risking to join our Safety & Exploratory Pharmacology group.The Safety & Exploratory Pharmacology department (SEP) collaborates with our discovery research, preclinical, and clinical development partners to identify and develop effective, safe therapeutics. To that end, SEP utilizes a purposeful blend of standard screening tools, regulatory-enabling assays, fit for purpose capabilities and forward-looking innovative solutions to understand potential major organ system pharmacodynamic risk and influence drug development strategy.To enhance that mission, we are looking for a PhD level individual contributor that will complement existing areas, expand the team's expertise, help drive future innovation, and influence the external scientific and regulatory community. The successful candidate will have demonstrated experience in areas detailed below and will possess the attributes and interest to expand their career toward a broader strategic Nonclinical Drug Safety role. This could include development toward future opportunities in management/leadership roles within SEP and/or as the nonclinical safety lead on discovery or clinical development programs.Education:
- PhD with 6+ years relevant post-degree experience in the development, execution and interpretation of in vitro exploratory or regulated nonclinical safety pharmacology/toxicology models.Required Experience and Skills:
- Ability to work both within teams as a contributor or as a team lead to drive collaborations across departments that deliver current needs and future capabilities.
- Experience in ion channel electrophysiology and its practical applications to standard screening and investigative models (ex: over-expressing cells, semi-automated platforms) to drive off target screening or enhanced mechanistic understanding of effects of major organ systems.
- Development and/or utilization of exploratory hIPSC-derived models (plate-based or 'organ-on-a-chip') or microphysiologic systems to enable issue-driven resolution and complement preclinical candidate selection and development.
- Experience either as a study director or contributing scientist for studies conducted under Good Laboratory Practices (GLP) that utilize common nonclinical in vitro test systems (e.g., best practice in vitro studies outlined in ICH E14 / S7B Q&A).Preferred Experience and Skills:
- Hands-on experience on patch clamp techniques and/or utilizing microelectrode arrays, impedance or imaging as readouts.
- Willingness and ability to investigate, develop and implement new technologies and capabilities to improve existing techniques and assays.
- Prior experience working in a multidisciplinary environment within the Pharmaceutical Industry, Regulatory Agencies, or Academic Institutions.
- Willingness to influence safety pharmacology science and the broader regulatory landscape through active participation in external consortiums, publications, and presentations at key scientific conferences.
- Experience or familiarity with biostatistics, programming, and/or data visualization tools.
- Experience in other safety pharmacology core areas (e.g., in vitro neuronal models to assess hyperexcitability risks). #J-18808-Ljbffr