Location: Beverly,MA, USA
Endolytix Technology Inc. is a well-funded startup biopharmaceutical company developing novel biological antibacterial therapeutics for a critical unmet need to transform the lives of patients with the most difficult infections to treat due to antibiotic resistance, drug toxicities, access, and reemergence post-therapy. We are in the Preclinical stage of development focused on scale-up process development for our lead drug formulation that consists of Enzymes encapsulated into liposomes.
We're seeking a highly skilled hands-on professional scientist to join a fast-paced biological formulations team at Endolytix. The successful candidate will provide expertise in formulations of biologicals as therapeutics. Responsibilities will include multiple aspects of formulations, protein biochemistry, and analytics to drive the development of novel medicines for the treatment of life-threatening bacterial infections for which there are no currently accepted treatments and a very poor success rate for the standards of care.
Apply here or on our website:
Job Responsibilities
· Formulation of enzymes in liposomes to optimize scaled-up process development
· Running of stability studies
· In-house scaled process development from 1 ml to 1 Liter preparation for pre-IND submission
· Working with CDMOs to transfer and support process development
· Biophysical characterization of proteins and liposomes using spectroscopy tools such as DLS, MADLS, UNCLE-derived Tm and Tagg, gel densitometry, and FFF-MALs
· Conceptual design, execution, and documentation of biochemical assays to characterize enzymes in and out of encapsulated liposomes
· Responsible for generating high-quality biochemical and biophysical data for particle analysis and stability
· Clear presentation of research outcomes and recommendations to multi-functional teams
· Perform drug purifications using Tangential Flow Filtration (TFF) and other methods
· Develop and collaborate externally on aerosol development
· Leadership for junior formulations staff
Required Qualifications
· Minimum of 5 years of pharma or biotech experience
· BS, MS, or Ph.D. in Biochemistry, Biophysics, or a related field
· Proven experience in developing lipid-based delivery vehicles of encapsulated biological API
· Proven experience in stabilizing biological formulations for improved efficacy
· Demonstrated ability to solve difficult problems in assay development and formulation science
· Relevant biological drug discovery experience working in a collaborative environment
· Startup company experience
· Effective communication both verbal and written for collaboration throughout the company
Preferred Qualifications
· Small scale manufacturing experience for non- and GLP drug product
· Experience taking drugs from discovery through subsequent drug development phases including animal studies, manufacturing, and IND submission
· Experience working with liposomes, micelles, nanoparticles, or related technologies
· Experience with statistical software such as JMP and experience running DOE
· Demonstrated flexibility to thrive in a team-oriented, fast-paced, technically challenging drug-hunting culture
· Experience with GMP manufacturing of biologicals
Equal Employment Opportunity Policy
It is the policy of Endolytix Technology, Inc. (“Endolytix”) to provide equal employment opportunities to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex (including sexual harassment and pregnancy discrimination), sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by federal, state or local law. In addition, Endolytix will provide reasonable accommodations for qualified individuals with disabilities.
These protections and principles guide all management practices and decisions, including recruitment and hiring practices, appraisal systems, promotions, training and access to career development programs. Endolytix managers and supervisors are responsible for preventing, documenting, and promptly correcting harassing conduct in the workplace.
Endolytix will not allow any form of retaliation against individuals who make good faith reports of alleged violations of this policy, or who cooperate in Endolytix's investigation of such reports, even if the reports do not reveal any wrongdoing.
Endolytix's policy is designed to comply with all applicable federal, state and local laws, rules and regulations and cover all human resource actions including employment, compensation, benefits, training, education, tuition aid, transfers, promotions and social/recreational programs.