Manager/Associated Director in Clinical Pharmacology Modeling and Simulation
: Job Details :

Site Name: USA - Pennsylvania - Upper ProvidencePosted Date: Dec 13 2024Are you energized by networking with key opinion leaders and leveraging your broad scientific expertise to accelerate the development of medicines? If so, this Clinical Pharmacology Manager role could be an exciting opportunity to explore.As a Clinical Pharmacology Manager, you will be responsible for providing deep scientific knowledge and expertise in early medicine development, and to work alongside other experts to relate these findings to the safety of medicines in patients.This role will provide YOU the opportunity to lead key activities to progress YOUR career, these responsibilities include some of the following…* Develop the scientific strategy, along with other experts, to improve our understanding of xenobiotic chemistry and their biotransformation pathways (structural alerts) and how these link to biological mechanisms of toxicity.* Collaborate with the Computational & Modelling Science group to integrate findings into qualitative systems biology models.* Work with Insight from Data and Computational & Modelling Science groups to help create knowledge databases to develop reports using retrospective and competitor information and establish relational rules for toxicity.* Advance our knowledge of the enzymes and their impact on preclinical-clinical translation (species differences) and prediction of clinical variability in patient populations (polymorphisms, impact of disease).* Evaluate/direct potential innovative drug metabolism/biotransformation research areas and/or apply innovative solutions to project problems, including design of bespoke studies and application of differential development.* Contextualize and extrapolate drug metabolism/biotransformation findings and discuss data with program/project teams, internal advisory groups as well as Senior Leaders & Regulators.* Represent GSK on external working groups to advance our understanding of drug metabolism / biotransformation mechanisms from preclinical findings to the clinical setting.* Communicate, interact and influence others and act as mentor, coach, trainer and consultant in understanding biotransformation pathways.Why you?Basic Qualifications:We are looking for professionals with these required skills to achieve our goals:* PhD in Biochemistry, Biological or chemistry sciences* Experience with drug metabolism with application to drug discovery and development* Strong experience with in vitro/ex-vivo technologies and in vitro/ex-vivo to in vivo extrapolation to investigative safety issues.Preferred Qualifications:If you have the following characteristics, it would be a plus:* Extensive knowledge chemistry of biotransformation or metabolism, and ability to apply this experience to drug discovery, development or post-marketing area issues.* Experience or working in matrix across departmental lines* Strong communication skillsWhy GSK?Our values and expectations are at the heart of everything we do and form an important part of our culture.These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:* Agile and distributed decision-making - using evidence and applying judgement to balance pace, rigour and risk.* Managing individual and team performance.* Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.* Implementing change initiatives and leading change.* Sustaining energy and well-being, building resilience in teams.* Continuously looking for opportunities to learn, build skills and share learning both internally and externally.* Developing people and building a talent pipeline.* Translating strategy into action - a compelling narrative, motivating others, setting objectives and delegation.* Building strong relationships and collaboration, managing trusted stakeholder relationships internally and externally.* Budgeting and forecasting, commercial and financial acumen.* This is a job description to aide in the job posting, but does not include all job evaluation details.Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.Why GSK?Uniting science, technology and talent to get ahead of disease together.GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-###-#### (US Toll Free) or +1 801 ### #### (outside US).GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.Important notice to Employment businesses/ AgenciesGSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. 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GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.