Job DescriptionTitle: Postdoctoral FellowSalary: $73,588Department: NeurosciencePhysical work location: (must be proper street address): 1425 Madison AveName PI or Supervisor: (include phone and email): Nan Yang; 212-###-####;w ...@mssm.edu;Web link to Lab: Web link to Department: ResponsibilitiesDetails of Research Project: The Department of Neuroscience at the Icahn School of Medicine at Mount Sinai is seeking highly motivated and talented postdoctoral fellows to join the laboratory of Nan Yang, Ph.D. Dr. Yang's lab is at the forefront of investigating the molecular and cellular mechanisms underlying neurodevelopmental, psychiatric, and neurodegenerative disorders, including autism spectrum disorder (ASD), bipolar disorder, Parkinson's disease, and Alzheimer's disease. The lab's research delves deeply into how disease-associated genetic variations impair neuronal properties and disrupt network activities, while also examining the early molecular and cellular events initiated by mutations identified through large-scale genomic studies.The lab employs a wide array of advanced techniques, ranging from CRISPR gene editing and brain organoid development to single-cell profiling and high-resolution imaging. Projects involve leveraging human stem cell-based and mouse models to explore fundamental questions in neuroscience, integrating electrophysiology, genetic and epigenetic analyses, live calcium imaging, and high-content imaging to uncover novel insights into disease mechanisms.As a postdoctoral fellow, you will lead innovative research projects under Dr. Yang's mentorship, utilizing state-of-the-art tools to investigate complex neurobiological processes. Your work will contribute to a vibrant and collaborative research environment, offering opportunities to engage with interdisciplinary teams both within Mount Sinai and across external institutions. This role provides a unique platform to push the boundaries of neuroscience research and make meaningful contributions to understanding and addressing critical brain disorders.Technical Duties: (include any protocols)
- Human Stem Cell and Mouse Model Work: Generate, maintain, and differentiate human stem cells and establish mouse models to study disease mechanisms at the molecular, cellular, and network levels.
- CRISPR Gene Editing and Screening: Design, implement, and troubleshoot CRISPR/Cas9-based gene editing and screening experiments to investigate the functional consequences of disease-associated genetic variations.
- Brain Organoid Development and Analysis: Develop and analyze 3D brain organoids to model neurodevelopmental and neurodegenerative processes.
- Single-Cell and High-Content Profiling: Conduct single-cell RNA sequencing and other high-throughput techniques to profile cellular and molecular changes in disease models.
- Advanced Imaging Techniques: Utilize high-resolution, live-cell, and calcium imaging to investigate dynamic cellular processes and interactions.
- Molecular and Cellular Assays: Execute standard and specialized molecular biology techniques, including qPCR, Western blotting, immunocytochemistry, and morphological analyses, to validate experimental findings. Perform detailed analyses of genetic and epigenetic datasets to uncover regulatory mechanisms associated with disease mutations.
- Collaboration and Data Sharing: Collaborate with team members and external researchers to integrate multidisciplinary techniques and communicate findings through presentations and publications.
Goals/Outcomes of the Research Project: The overarching goal of the lab's research is to uncover fundamental mechanisms that drive brain disorders and identify critical molecular and cellular pathways as potential therapeutic targets. By combining human stem cell-based and mouse models with cutting-edge approaches such as CRISPR gene editing, single-cell profiling, and brain organoids, the lab aims to bridge the gap between genomic discoveries and functional understanding, paving the way for novel strategies to prevent or treat neurological diseases.QualificationsEducational and other Requirements for the position:
- Ph.D., MD/Ph.D. in Neuroscience/Molecular Biology/Cellular Biology;
- Demonstrated expertise in neuroscience;
Experience Required:
- Experience with human stem cell cultures or animal models studying brain development and
function;
- Familiar with basic neuroscience tools, such as calcium imaging, high content imaging and mophological analyses, recordings
SPOC-UAW Local 4100 at Icahn School of Medicine (Post Docs), 867 - Neurosciences - ISM, Icahn School of MedicineEOE Minorities/Women/Disabled/VeteransThe Mount Sinai Health System is an equal opportunity employer. We comply with applicable Federal civil rights laws and does not discriminate, exclude, or treat people differently on the basis of race, color, national origin, age, religion, disability, sex, sexual orientation, gender identity, or gender expression. We are passionately committed to addressing racism and its effects on our faculty, staff, students, trainees, patients, visitors, and the communities we serve. Our goal is for Mount Sinai to become an anti-racist health care and learning institution that intentionally addresses structural racism.?About Us
Strength Through Diversity The Mount Sinai Health System believes that diversity, equity, and inclusion are key drivers for excellence. We share a common devotion to delivering exceptional patient care. When you join us, you become a part of Mount Sinai's unrivaled record of achievement, education, and advancement as we revolutionize medicine together. We invite you to participate actively as a part of the Mount Sinai Health System team by:
- Using a lens of equity in all aspects of patient care delivery, education, and research to promote policies and practices to allow opportunities for all to thrive and reach their potential.
- Serving as a role model confronting racist, sexist, or other inappropriate actions by speaking up, challenging exclusionary organizational practices, and standing side-by-side in support of colleagues who experience discrimination.
- Inspiring and fostering an environment of anti-racist behaviors among and between departments and co-workers.
At Mount Sinai, our leaders strive to learn, empower others, and embrace change to further advance equity and improve the well-being of staff, patients, and the organization. We expect our leaders to embrace anti-racism, create a collaborative and respectful environment, and constructively disrupt the status quo to improve the system and enhance care for our patients. We work hard to create an inclusive, welcoming and nurturing work environment where all feel they are valued, belong and are able to advance professionally. Explore more about this opportunity and how you can help us write a new chapter in our history!
About the Mount Sinai Health System: Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 43,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time - discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients' medical and emotional needs at the center of all treatment. The Health System includes approximately 7,400 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high Honor Roll status, and are highly ranked: No. 1 in Geriatrics and top 20 in Cardiology/Heart Surgery, Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report's Best Children's Hospitals ranks Mount Sinai Kravis Children's Hospital among the country's best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 14 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek's The World's Best Smart Hospitals ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally. The Mount Sinai Health System is an equal opportunity employer. We comply with applicable Federal civil rights laws and does not discriminate, exclude, or treat people differently on the basis of race, color, national origin, age, religion, disability, sex, sexual orientation, gender identity, or gender expression. We are passionately committed to addressing racism and its effects on our faculty, staff, students, trainees, patients, visitors, and the communities we serve. Our goal is for Mount Sinai to become an anti-racist health care and learning institution that intentionally addresses structural racism.
EOE Minorities/Women/Disabled/Veterans