Location: Allston,MA, USA
A career at Resilience is more than just a job – it's an opportunity to change the future.
Resilience is a technology-focused biomanufacturing company that's changing the way medicine is made. We're building a sustainable network of high-tech, end-to-end manufacturing solutions to better withstand disruptive events, serve scientific discovery, and reach those in need.
For more information, please visit www.resilience.com
Resilience is seeking a highly experienced and scientifically-driven Principal Scientist – Cell Line Development, who will lead the mammalian Cell Line Development function for the Biologics, Vaccines, and Gene Therapy modalities. This leader will play a critical role in revolutionizing the way drugs are developed and manufactured at Resilience. Reporting to the Head of Process Development – Boston, the Principal Scientist – Cell Line Development will be accountable for the flawless execution of the Cell Line Development activities, spanning mammalian cell line culture and development, vector construct development, mammalian cell line engineering, cell line characterization and stability testing, single cell cloning, as well as optimization of processes and assays. The Principal Scientist is also responsible for HEK 293 cell line engineering to generate an AAV or LVV packaging line, vector design, evaluation of production and gene incorporation. In addition, this role is responsible for developing the strategy to achieve implementation of stable pools and cell lines, as well as, supporting the regulatory advancement of fully integrated cell lines. This leader will be responsible for driving a deeply scientific and customer enabling culture. A key aspect of the role will be the technical mentorship of the staff and the ability to raise their technical expertise through close interaction and mentorship. The successful candidate must have hands-on background in development and GMP implementation of cell lines and cell banks, knowledge of complex scientific principals and concepts in fields of cell biology, protein expression, molecular biology, and/or protein engineering, including plasmid design, CRISPR or transposase mediated GOI insertion, viral capsid production, stable and transient transfections, clone screening, small scale bioreactors, and DNA cloning and PCR.
Job Responsibilities
Minimum Experience
Preferred Experience, Education & Qualifications
Resilience is an Equal Employment Opportunity Employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender perception or identity, national origin, age, marital status, protected veteran status, disability status, physical or mental disability, genetic information, or characteristic, or other non-job-related characteristics or other prohibited grounds specified in applicable federal, state, and local laws. Requests for reasonable accommodation can be made at any stage of the recruitment process.
Resilience offers employees a robust total rewards program including equity, an annual cash bonus program, a 401(k) plan with a generous company match and our benefits package which is thoughtfully designed to support our employees with great healthcare (including medical, dental and vision), family building benefits, life and disability insurance, flexible time off, paid holidays, other paid leaves of absence, tuition reimbursement and support for caregiving needs. Our target base pay hiring range for this position is $150,000.00 - $225,000.00 per year. Actual base pay is dependent upon a number of factors, including but not limited to, the candidate's geographical location, relevant experience, qualifications, skills and knowledge. Excited about Resilience and the biomanufacturing revolution? We encourage you to apply and start a conversation with one of our recruiters.