About > Employment > Sr Principal ScientistJob Title: Principal Scientist/Senior Principal ScientistField: Immunology and InflammationCompany: Harbour BioMedLocation: Newton/Boston, MA, USACompany DescriptionHarbour BioMed is a biopharmaceutical company headquartered in Shanghai with business operations and research centers in Boston and Netherlands. Harbour BioMed leverages its proprietary transgenic mice to develop innovative, therapeutic, and fully human monoclonal antibodies against diseases with unmet medical needs.We are seeking highly motivated immunologists to join its Immunology and Inflammation team.Key Responsibilities
Lead immunology discovery projects and champion projects from discovery into early clinical development. Develop and execute efficient strategies for target identification, prioritization, and validation; review, propose, initiate, and implement new pre-clinical therapeutic antibody drug discovery and development programs in the field of Immunology and Inflammation. Represent in-house expertise in one or more areas of T cells, macrophages/DC, NK cells, ILC, or B cells. Collaborate with CRO and academic partners; employ cutting-edge in vitro and in vivo animal and human models to advance drug discovery and development programs up to and including IND filing. Collaborate with clinical and business units to support clinical studies. Lead project team meetings, and present updates to senior management. Facilitate the writing of patents and regulatory documents. Present non-proprietary results at scientific conferences and publish in peer-reviewed journals.Essential Qualifications - PhD in immunology or related discipline;
- 2-4 years of postdoctoral experience in immunology or related field;
- More than 5 years of industrial experience, ideally in the field of immunology.Preferred Qualifications
- Demonstrated track record of independent critical thinking and scientific achievement in research, exemplified by strong publications in leading journals;
- Experience of leading a drug discovery project in biopharmaceutical companies;
- Expertise of in vitro primary immune cell-based functional assays;
- Extensive experience in flow cytometry, as well as molecular and cellular biology;
- Knowledge and/or skills of in vivo models of immuno-inflammatory diseases;
- Understanding of fundamentals and practice of antibody discovery, engineering, and development;
- Excellent written and oral communication skills, as well as people organizational skills;
- Enthusiasm in laboratory experimentation. #J-18808-Ljbffr