Location: Durham,NC, USA
Asklepios BioPharmaceutical, Inc. (AskBio) is a leading, clinical-stage gene therapy company founded in 2001 based on the work of adeno-associated virus (AAV) gene therapy visionary and pioneer, Jude Samulski, PhD. Since that time, our commitment to developing life-saving medicines that can potentially cure genetic diseases has never wavered.
At AskBio, we've built a foundation of therapeutic programs, AAV manufacturing and a rich portfolio of patented technology. Our therapeutic focus includes neuromuscular, central nervous system, cardiovascular and metabolic diseases with clinical trials underway for Pompe disease, Parkinson's disease, and congestive heart failure. Our gene therapy platform includes Pro10, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library.
We became a wholly-owned, independently operated, subsidiary of Bayer AG in late 2020 as a cornerstone of its newly formed Cell & Gene Therapy (CGT) platform. Our global headquarters is in Research Triangle Park, NC. Additionally, we have significant operations in Philadelphia, PA, Columbus, OH, Scotland, France, Germany, and Spain.
Our vision: Pioneering science to create transformative molecular medicines.
Our mission: Lead innovative science and drive clinical outcomes to transform people's lives.
Our principles:
* Advance innovative science by pushing boundaries.
* Bring transformative therapeutics to patients in need.
* Provide an environment for employees to reach their fullest potential.
Our values:
* Be a Pioneer. We are not afraid of the impossible and to innovate to make gene therapies accessible to those in need.
* Cultivate Collaboration. Strive to be the best teammate, actively listen, openly communicate, and embrace diverse points of view.
* Embrace Responsibility. We are humbled by the enormity of our mission. We hold a relentless commitment to advance science and clinical outcomes for our patients, families, and caregivers.
* Raise the Bar. Continuously drive improvements and efficiencies. Seek and provide constructive feedback. Have a bias for learning and action.
* Act with Uncompromising Integrity. Be honest, transparent, and committed to doing what's right in every situation. Make clear commitments and follow through.
The Research Associate I, Downstream Process Development will contribute to the development of downstream processes for different gene therapy programs. The individual will understand downstream unit operations such as chromatography, tangential flow filtration and depth filtration. The candidate will be primarily responsible for executing laboratory studies related to process development, process understanding and scale up. The successful candidate will support experimental setup and laboratory management activities in addition to supporting drafting of batch records, reports, and data worksheets. This role will sit onsite at AskBio headquarters in Research Triangle Park, RTP, NC.
Responsibilities
* Apply laboratory experience to execute depth filtration, tangential flow filtration and chromatography unit operations with minimal supervision.
* Record experimental activities and data in batch records as per Good Documentation Practices.
* Support writing technical documentation such as protocols and reports under guidance of program leads.
* Perform experimental setup and post execution activities including CIP procedures, buffer preparation, equipment calibration, sample labelling and analytical sample submissions.
* Support maintenance of analytical database by data entry and verification.
* Work in a team setting as well as independently on different programs to meet the deliverables under the scheduled timelines.
* Actively participate as a member of multifunctional project teams
Minimum Requirements:
* BS degree in Biology/Biochemistry/Chemistry/Chemical Engineering
* Basic knowledge of depth filtration, chromatography and tangential flow filtration unit operations for biologics purification
* Experience working in team setting as well as on individual projects
* Experience in Good Documentation Practices
Preferred Skills & Experience:
* Hands on lab experience preferably in downstream unit operations
* Lab based internship or academic laboratory work experience
Asklepios BioPharmaceutical, Inc. (AskBio) is an Equal Opportunity Employer and does not discriminate against any employee or applicant for employment because of race, color, religion, gender, sexual orientation, gender identity, national origin, age, disability, veteran status or any other protected status prohibited under Federal, State or local laws. All employment decisions are based on valid job?related requirements. If you are a qualified individual with a disability or a disabled veteran and are unable or limited in your ability to use or access our website, you may request a reasonable accommodation to express interest in a specific opening by calling us at (919) ###-#### or sending us an email at ...@askbio.com.
Agencies: Please do not contact any employee at AskBio about this requisition. Any resume submitted by a recruitment agency to any employee at AskBio, through any medium, will be deemed the sole property of AskBio unless the agency was engaged by AskBio Talent Acquisition team to recruit for that position. All agencies must have a prior executed service agreement with AskBio prior to any search engagement. If a candidate who was submitted outside of the AskBio agency process is hired by AskBio, no fee or payment of any kind will be paid to the agency.