Location: San Diego,CA, USA
About Valora Therapeutics Inc.:
Valora Therapeutics Inc. (Valora) is a pre-clinical stage biopharmaceutical company based in San Diego, California, USA, pioneering a new biologic platform invented by Nobel Laureate Dr. Carolyn Bertozzi (Stanford). Our proprietary platform technology enables the engineering of chimeric antibodies to unlock new mechanisms of immune signaling and activity, paving the way for transformative therapies in oncology, immune diseases, and beyond.
About the Opportunity:
Valora is excited to expand our Immunology team and is looking for a highly motivated scientist to support our R&D Operations in developing next-generation antibody therapeutics using our proprietary chimeric antibody platform. This role will focus on hands-on laboratory work and will include activities such as the following:
In this position, you will:
· Assist in the design and execution of experiments to evaluate novel engineered antibodies, applying critical thinking and problem-solving skills.
· Develop and optimize in vitro and ex vivo assays to elucidate cellular and molecular immunological mechanisms.
· Analyze datasets, interpret results, and contribute to presenting findings to cross-functional teams.
· Contribute to the development of new hypotheses and experimental approaches in team discussions.
· Stay current with advancements in immunology and antibody engineering, applying this knowledge to ongoing projects.
About You:
Education and Experience:
Technical Skills and Knowledge:
a) Functional assays such as: (1) Cytotoxicity assays (e.g., 51Cr release, LDH release, real-time cell analysis), (2) Proliferation assays (e.g., CFSE dilution, 3H-thymidine incorporation), (3) Cytokine production and secretion assays (e.g., ELISPOT, intracellular cytokine staining), (4) Antibody-dependent cellular cytotoxicity/phagocytosis (ADCC/ADCP) and complement-dependent cytotoxicity (CDC) assays
b) Multi-color flow cytometry for immunophenotyping and functional readouts
c) MSD, Luminex, or other multiplex assays for analyte measurement
d) Molecular immunology assays to interrogate signaling pathways and evaluate mechanisms of action
General Scientific Skills:
Personal Qualities:
We Offer:
· The opportunity to be at the forefront of groundbreaking antibody therapeutic development.
· A collaborative and supportive team environment with a highly dynamic and entrepreneurial environment.
Compensation:
In addition to a competitive compensation package with stock options, the company also offers a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, and supplemental disability insurance.
Job Type:
Full-time, 5 days a week presence at the laboratories (this is not a remote work).
Supplemental Pay Types:
Bonus pay, stock options
Benefits:
Join Valora Therapeutics and unleash the potential of protein engineering to revolutionize medicine!