Job Title: Quality - Research Scientist Qty: 1 Location: San Diego, CA 92121 Duration: 12 Months The starting hourly compensation may be subject to change.Top Skills:
- Ph.D. in cell biology, immunology, molecular biology, oncology or equivalent field
- Knowledge and experience in using multi-parameter flow cytometry
- Hands-on experience with mammalian cell culture, molecular and cellular technologies (e.g., CRISPR/Cas9 knock-in/out, lentiviral transduction, western blotting, quantitative PCR,) and functional assays (e.g., proliferation, apoptosis, cell cycle) is essential
- Experience in utilizing platforms including IncuCyte, JESS, Flow based cell sorter, ELISA, and MSD in the context of oncology-based drug discovery is a plus
Responsibilities
- Utilize and develop multiple disease models to design target validation studies and relevant assays in support of SAR, mechanism of action, mechanisms of resistance, biomarker selection, and disease positioning.
- Develop and implement cell-based assays to address both tumor intrinsic cellular biology and immune-based mechanisms of action for potential drug candidates
- Design and conduct essential mechanistic experiments in cell biology, cellular biochemistry, molecular biology, and assay development
- Accurately maintain written reports and present results in an organized and timely manner.
- Communicate effectively, foster teamwork, and contribute to collaborative efforts.
- Strong commitment to quality and demonstrate adaptability.
Qualifications:
- Ph.D. in cell biology, immunology, molecular biology, or equivalent field with 0-2 years of post-doc or industry experience, or M.S. degree with 3+ years of experience, or Bachelor's degree with 5+ years of experience in the biopharmaceutical industry developing and optimizing cell-based assays, preferably in Oncology
- Strong background and experience in cancer research with training in molecular and cell biology
- Extensive experience using multi-parameter flow cytometry in the context of primary immune cell isolation and characterization is required.
- Extensive hands-on experience with mammalian cell culture, molecular and cellular technologies (e.g., CRISPR/Cas9 knock-in/out, lentiviral transduction, western blotting, quantitative PCR,) and functional assays (e.g., proliferation, apoptosis, cell cycle) is essential
- Experience in utilizing platforms including IncuCyte, JESS, Flow based cell sorter, ELISA, and MSD in the context of oncology-based drug discovery is a plus.
- Strong record of high-impact and rigorous science though publication history.
- Proficiency in scientific data analysis programs including GraphPad Prism, FlowJo, Microsoft Excel/Powerpoint, is required
- Capability to deliver high quality data in an organized and timely manner
- Ability to work in a fast-paced dynamic team environment; flexibility to adapt to changes with a positive attitude and independently collaborate across teams, requiring excellent communication skills, both written and verbal, with strong interpersonal skills.