Scientific - Senior Research Associate
: Job Details :

Job Title: Scientific - Senior Research AssociateLocation: San Diego, CA - 92121Note: 100 % onsiteJob Description100% Onsite The Oncogenesis TRC at Bristol Myers Squibb (BMS) focuses on delivering novel cancer therapeutics by engaging E3 ubiquitin ligases for targeted protein degradation. We are seeking a motivated Senior Research Associate with broad experience and understanding of the small-molecule drug discovery processes. The successful candidate will work collaboratively in a multi-disciplinary environment to 1) develop and implement robust cellular assays to support discovery of small molecules as clinical development candidates; and 2) execute in vitro studies that further our understanding of the mechanisms of novel compounds. The desired candidate should have experience in cell biology, biochemistry, in vitro cell culture techniques. Responsibilities include utilizing cellular models to develop and execute cell line construction, gene editing and development of new in vitro assays. The candidate will work within discovery project teams and with scientists across different functional areas and is expected to contribute to project based decisions. Responsibilities will include but are not limited to the following: 1. Develop and implement relevant cell-based and biochemical assays to support identification, optimization, and characterization of novel chemical matter 2. Develop and construct cell lines and tools for Mechanism of Action (MoA) studies 3. Design and conduct critical experiments using expertise in cell biology, molecular biology, biochemistry and assay development to support MoA studies 4. Execute routine assays for Structure Activity Relationship (SAR) support in a consistent and timely manner 5. Document, analyze, and present data in an organized and timely manner 6. Support biology needs for different projects and drug discovery teams Requirements: 1. Bachelor's degree in biology with a minimum of 3 years of experience or Master's Degree with a minimum of 1 year experience 2. Excellent sterile technique with mammalian cell culture is required. Experience with transfection, lentiviral transduction, CRISPR KO, shRNA knock downs, or organoid culture is a plus. 3. Experience with molecular techniques such as western blotting, cloning, DNA and RNA isolation. 4. Deep understanding and willingness to learn in vitro cell-based assays, including but not limited to: cell proliferation assays, cell cycle assays, apoptosis assays, MSD, incucyte, and flow cytometry 5. Data analysis and data handling skills including Excel, PowerPoint, GraphPad PRISM, and importing/exporting data into/from databases 6. Capability to stay focused, attention to details and deliver high quality data in a consistent, timely, and well-organized manner. 7. Motivated to learn and passionate about cancer therapeutics discovery and research 8. Excellent communication, presentation, collaboration, and organizational skills. 9. Ability to handle multiple projects and work in a fast-paced dynamic team environment