Location: Cambridge,MA, USA
Scientist Physico-Chemical Analytical Platform US
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At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease.
We believe the Greater Boston area is an important hub for the biotech and pharma industry, which is why we've invested in growing our footprint and expanding our R&D space in Cambridge, with a primary focus on additional state-of-the-art lab space. Here, we will bring together talent and expertise, building upon GSK's long history of vaccine development, to create globally leading viral capabilities and cutting-edge vaccines technologies, as we add to our robust portfolio targeting infectious diseases at every stage of life.
In the plan to create a new hub for mRNA-based vaccines in Cambridge, we are building new laboratories that will be focused on mRNA state-of-the-art platforms that will enable the discovery and early development of new products including deep product understanding, novel delivery systems and advanced characterization at preclinical as well as clinical stages, supporting the introduction of new mRNA-based vaccines.
The new Physico-Chemical US platform will be focusing on a panel of technologies including and not limited to MS, Chromatography, Electrophoresis, Spectroscopy analyses, dimensional testing and miscellaneous physico-chem techniques used to characterize macromolecules, e.g. mRNA and proteins. The Physico-Chem US platform is an integral part of the global analytical platform also based in Belgium and Italy, where method development, qualification, and validation as well as GMP activities (release and stability) are executed.
The Scientist Physico-Chem US is expected to design and execute scientific studies in support of technical programs as they progress from development into early clinical Phases. The candidate will therefore contribute to the implementation of innovative and cutting-edge analytical methods combining all physico-chem/separation technologies for mRNA and macromolecule (proteins) characterization and testing in line with Quality by Design (QbD) principles in the mentioned technical area.
The candidate will participate to experimental activities according to defined priorities and is responsible for the quality of data and presentation of results to internal and external audiences.
Key Responsibilities:
* Be part and an active member of a High-Performing Team of top scientists driven by innovation, quality and excellence.
* Cultivate department culture: excellence in science and operations, embracing an open global mindset, fostering a positive culture of transparency and collaboration within the global organization.
* Deliver expectations for the following missions:
* Develop next generation analytical methods for next generation mRNA vaccines using innovative Phys-chem/separation technologies and automation in collaboration with the other teams of the global analytical platforms.
* Apply/execute these methods to early mRNA candidate vaccines in close collaboration with Preclinical, Drug Substance (DS) and Drug Product (DP) teams for deep product understanding, process development support at the preclinical, DS and DP stages.
* Excel in delivering quality data and sound science to drive decisions for new vaccine candidate projects, as part of end-to-end accelerated vaccine CMC development programs.
* Design and drive the development of innovative analytical methods for vaccine early development phases and integrate it into the end-to-end CMC strategy. Collaborate closely with the Preclinical, Drug Substance and Drug Product departments, as well as with the other ARDS platforms and other stakeholders to ensure timely delivery.
* Act as a key subject matter expert: think out-of-the-box, using sound science, paying attention to details to continuously improve and shape the CMC strategy & framework.
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The successful applicant will spend 3-6 months within the first year in Rockville, MD to support and guarantee a smooth transition of methods and know-how to the new laboratories in Cambridge, MA.
Basic Qualifications:
We are looking for professionals with these required skills to achieve our goals:
* MS or PhD in Chemistry, Biology, Biochemistry, Biotechnology, Bioengineering, Chemical Engineering, or a related scientific field.
* MS candidates should have three or more years of additional laboratory experience. PhD with no additional laboratory experience is acceptable.
* Two or more years of experience in Phys-Chem/Separation based technologies.
Preferred Qualifications:
* A good understanding of biopharma / vaccine development process.
* Has worked in a multi-disciplinary team, demonstrates skills in combining different analytical technologies (immuno-cellular, cellular-molecular, immuno-molecular) in the field.
* Strong experience and understanding of molecular biology and analytical development.
* Fluency in English
* Good understanding of QbD principles. Driven by excellence, creativity, accountability, and flexibility in a collaborative and innovative environment.
* Capacity to synthesize messages and ability to defend scientific and technical decisions to have constructive interactions and take the right decisions with other Leaders.
* Must have the ability to work with cross-functional teams.
* Superlative presentation skills, across lines and levels and with senior stakeholders.
* Problem-solving ability with limited information available to make decisions and interpretations.
* Anticipates medium/long-term future issues.
* Positive, open and can-do mindset.
* Critical thinking ability is a must.
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Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.
Why GSK?
Uniting science, technology and talent to get ahead of disease together.
GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).
Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.
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