Scientist/Senior Scientist (Islet Cell Therapy)
: Job Details :

As the leading global type 1 diabetes (T1D) research and advocacy organization, Breakthrough T1D helps make everyday life with T1D better while driving toward cures. We invest in the most promising research to turn ideas into life-changing therapies and devices. We work with government, regulatory officials, and insurance companies to address issues that impact the T1D communitybreaking through barriers that limit access to care worldwide. We provide resources and guidance that makes it easier to live and thrive with T1D. This is more than a momentwe're empowering a movement for the T1D community. Share your support and help educate and empower individuals facing type 1 diabetes.Our mission is to improve lives today and tomorrow by accelerating life changing breakthroughs to treat, prevent and ultimately, cure T1D and its complications. Always, we are guided by a single purpose: As we drive towards curing type 1 diabetes, we help make everyday life better for the people who face it.This is a hybrid position based out of the NYC office.BREAKTHROUGH T1D is hiring to fill a Scientist position within the Research Department to work in the BREAKTHROUGH T1D Cures portfolio and help us achieve our vision of a world without T1D through the development of islet cell replacement therapies. (For more information on the Cures Program's scientific strategy visit our website: . The new Scientist will be part of a highly interconnected and fast-moving team that is responsible for setting and driving BREAKTHROUGH T1D 's research strategy for T1D. While working primarily on the Islet Cell Therapy project, the scientist will have the opportunity to work in other areas within the Cures Program including Prevention/Early Detection of T1D and Disease Modifying Therapies areas.The scientist will be responsible for building and actively managing a portfolio of cutting edge research and development projects with a diverse range of partners including world leading scientists in academia, industry, other funding organizations, and others both in the United States and across the globe. In this role the scientist will have the opportunity to develop new scientific projects which are often built collaboratively with the scientific community and maintain regular contact with funded investigators to monitor BREAKTHROUGH T1D 's active portfolio. The scientist must demonstrate creativity, scientific rigor to advance the field and ability to think strategically. Due diligence and landscape analyses activities are a requisite part of this proactive portfolio management. The scientist will serve as an internal expert in their specialty areas and function as a knowledge resource internally and externally. Our mission is highly focused on developing curative therapies and improving the outcomes or people living with T1D, so the candidate should have a strong interest in human diseases and understand the basic concepts of discovery and translational research. Experience with product development and translational research is desired but not required.In this role, the scientist will also be responsible for communicating BREAKTHROUGH T1D research strategy and progress with various stakeholders ranging from internal and external scientists, board members, senior management, BREAKTHROUGH T1D supporters and volunteers. Therefore, strong interpersonal and communication skills are key. BREAKTHROUGH T1D scientists develop and deliver presentations for live audiences and contribute to various sorts of written documents about the research we support.This position will report to the Associate Director of Research overseeing the Cell Therapy portfolio and will participate in all aspects of the BREAKTHROUGH T1D research program including providing scientific input to accelerate the progress of therapeutic areas, contributing to future research strategies aligned with BREAKTHROUGH T1D 's mission, and leveraging opportunities and optimizing relationships within the US and international research communities.SPECIFIC RESPONSIBILITIES: Strategy and Planning

• Contribute expertise to strategic planning efforts to advance the Islet Cell Replacement portfolio in areas of immunology, cell/organ transplantation, allogenic rejection, autoimmunity, stem cell development, gene editing, xenotransplantation, engineering, biomaterial science and others.
• Maintaining up-to-date scientific knowledge in T1D-relevant areas
• Analyze scientific and commercial landscapes to determine how BREAKTHROUGH T1D can maximize our impact
• Contribute to the regular assessment, review, and presentation of the status of the research portfolio to the Board of Directors and external scientific advisors.

Pre-award and active portfolio management

• Development of new research opportunities with internal and external stakeholders (academic scientists, industry partners, etc.).
• Participation in scouting, securing, and managing research partnerships with companies, other non-profit organizations, governmental agencies, etc.
• Collaborate with other BREAKTHROUGH T1D scientists and non-scientific staff (program administrators, clinical trial managers, business development colleagues, regulatory and health policy experts) to identify gap-filling funding opportunities
• Internal review and management of external peer review of funding opportunities.
• Active management of ongoing grants.
• Work closely with program administrators to plan, track, and execute on the research budget.

Communication

• Generate and deliver presentations on BREAKTHROUGH T1D Research strategy and progress to lay and expert stakeholders.
• Create content for public media outlets in collaboration with internal Marketing and Communications team.

Note that experience performing the Specific Responsibilities listed above is not a prerequisite for the position, but an enthusiasm to learn is.Qualifications

• Ph.D. (or equivalent degree) in biomedical sciences with 3-4 years of postdoctoral experience in drug or product prototype development preferred. Title will be commensurate with qualifications and experience.
• Working expertise in one or more of the following areas required:
  • Stem cell biology
  • Beta cell biology
  • Immunology
  • Human genetics
  • Mechanisms of human diseases, especially autoimmune disease
  • Allo- and xenogeneic cell/organ transplantation
  • Regenerative medicine
  • Cell/tissue engineering
  • Gene editing
  • Other areas of interest: implantable scaffolds, vascularization, cell encapsulation, controlled drug delivery, immune engineering.
  • Design and operation of partnered research projects, including complex projects and consortia involving multiple collaborators, and across academia and industry

• Ability to create, operate and innovate within highly connected team environments with high level of independence.
• Exceptional collaboration and relationship-building skills. Ability to interface with stakeholders of highly diverse backgrounds, including staff and volunteers. Must develop, maintain, and cultivate relationships.

• Demonstrate creativity and ability to think strategically regarding scientific and technical opportunities or roadblocks, and to conceive and execute on projects.
• Ability for and interest in developing expertise in new scientific areas
• Excellent written and oral communication skills.

Additional InformationBREAKTHROUGH T1D supports a diverse and inclusive workforce and is an Equal Opportunity Employer. Your information will be kept confidential according to EEO guidelines. All your information will be kept confidential according to EEO guidelines.Domestic and international travel may be required. Applicants are strongly encouraged to provide a cover letter.Target Salary - $90k - $105kEssential Functions:The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this position. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.While performing the duties of this position, the employee is regularly required to talk or hear. The employee frequently is required to use hands or fingers, handle or feel objects, tools or controls. The employee is occasionally required to stand, walk, sit, reach with hands and arms, climb or balance, and stoop, kneel, crouch or crawl.The employee must occasionally lift and/or move up to 25 pounds, and infrequently up to 50 pounds. Specific vision abilities required by this position include close vision, distance vision, color vision, peripheral vision, and the ability to adjust focus.The noise level in the work environment is usually moderate.Additional information:Requests for medical, religious, and other exemptions will be considered on an individual basis. Breakthrough T1D will comply with all federal, state, and local laws.Breakthrough T1D supports a diverse and inclusive workforce.Breakthrough T1D is an Equal Opportunity Employer. All your information will be kept confidential according to EEO guidelines.