Company Overview
Since its inception over a decade ago,CRISPR Therapeuticshas transformed from a research-stage company advancing programs in the field of gene editing, to a company with a diverse portfolio of product candidates across a broad range of disease areas including hemoglobinopathies, oncology, regenerative medicine, cardiovascular and rare diseases. The Nobel Prize-winning CRISPR science has revolutionized biomedical research and represents a powerful, clinically validated approach with the potential to create a new class of potentially transformative medicines. To accelerate and expand its efforts,CRISPR Therapeuticshas established strategic partnerships with leading companies includingBayerand Vertex Pharmaceuticals.CRISPR Therapeutics AGis headquartered inZug, Switzerland, with its wholly-ownedU.S.subsidiary,CRISPR Therapeutics, Inc., and R&D operations based inBoston, MassachusettsandSan Francisco, California, and business offices inLondon, United Kingdom.
Position Summary
Responsible for in vivo research design and execution across our next-generation editing modalities team, we are looking for a motivated and independent researcher/scientist with preclinical & in vivo gene therapy experience who is excited by the opportunity to develop innovative gene editing technologies. This individual will be involved in both hands-on in vivo research and strategic planning of early-stage discovery and preclinical project(s).
Opportunities in this role include designing our translational in vivo research strategy to evaluate next-gen editing technologies, ensuring appropriate resourcing for, and execution of, all preclinical in vivo studies and reports within the CRISPR-X research team, authoring preclinical content for global regulatory submissions, and providing input into senior-level governance activities and global safety reviews, as appropriate.
Responsibilities
- Lead, design, and execute research with the aims of exploring and developing next-generation gene editing strategies using CRISPR-based tools and beyond.
- Responsible for in-vivo research and execution across our next-generation modalities, covering hepatic and extra-hepatic target tissues. Lead and conduct hands-on in-vivo research and strategic planning of preclinical projects.
- Opportunities include designing translational in-vivo research strategies to evaluate novel editing modalities, ensuring appropriate resourcing for, and execution of, preclinical in-vivo editing studies as part of the CRISPR-X team, and authoring preclinical content for global regulatory submissions.
- Design, execute, and interpret research requiring in-vivo biology methods including generation, breeding, and maintenance of genetically engineered mouse models; various injection and animal surgery techniques; in-vivo assessment of biomarkers and editing outcomes; longitudinal study of animal health, disease markers, and phenotypic assays; post-mortem preparation of tissue sections, IHC, and other assays.
- Analyze and present experimental data to a wide range of audiences.
- Dissect published literature to find novel solutions to gene editing problems.
- Generate, manage, evaluate, and maintain critical data in a highly organized manner, providing statistical analysis and troubleshooting where appropriate.
- Oversees the construction and maintenance of technical databases, archives and department procedures manuals required for the CRISPR-X function.
Minimum Qualifications
- Extensive prior experience with general animal procedures, familiarity with in-vivo gene editing, including applying and developing next generation gene editing technologies, such as prime editing, base editing, and recombinases and retrotransposons, in an academic and/or industry setting, with a track record demonstrating significant contributions.
- Depending on level, degrees in Biology, Bioengineering, or related disciplines (level commensurate with experience and achievement):
- Scientist I – PhD with 0-3 years relevant experience; non-PhD with 8-10 years progressive, relevant experience
- Scientist II - PhD with 2-5 years relevant experience; non-PhD with 10-12 years progressive, relevant experience
- Senior Scientist - PhD with 4-8 years relevant experience; non-PhD with 12-15 years progressive, relevant experience
- Excellent technical skills for rodent (mouse and rat) in vivo work comprising but not limited to IV injections, blood collection, necropsy.
- Experience managing multiple programs and priorities, studies, external CRO management, and budgets.
- Strong communicator and activator personality.
- Highly collaborative team player within and across multiple departments.
- Ability to manage and teach while still being hands on.
Preferred Qualifications
- Knowledge and experience in advanced in vivo techniques such as liver perfusion and hepatocyte isolation, and/or measuring lung function.
- Deep understanding of rodent (mouse and rat) in vivo techniques ranging from surgical procedures on neonates to physiological and pathological assessment of diseased adult rodents
Competencies
- Collaborative – Openness, One Team
- Undaunted – Fearless, Can-do attitude
- Results Orientation – Delivering progress toward our mission. Sense of urgency in solving problems.
- Entrepreneurial Spirit – Proactive. Ownership mindset.
Due to the nature of their work, our manufacturing and lab-based positions are located fully on-site.
CRISPR Therapeutics, Inc. is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.
To view our Privacy Statement, please click the following link:
#J-18808-Ljbffr