Location: Gaithersburg,MD, USA
Senior Scientist - IO Discovery
Gaithersburg, MD
Join our Immuno-Oncology Discovery team at AstraZeneca in Gaithersburg, MD as a Senior Scientist. We are seeking a highly motivated individual with strong scientific and broad technical expertise in human immunology. Our department is at the forefront of developing immunotherapies that boost immune responses in tumors, with a focus on novel approaches to drug discovery. As a member of our team, you will design, conduct, and analyze in vitro experiments to assess novel immunological mechanisms and therapeutics. This is an exciting opportunity to contribute to the development of novel treatments for oncology patients.
Accountabilities:
As a Senior Scientist, you will apply your technical and scientific experience to design, conduct, and analyze in vitro experiments using primary human immune cells. This role is lab based and will be an individual contributor. You will be involved in designing and performing activity assays and mechanism of action studies for therapeutic and tool molecules. You will stay up to date with the latest discoveries in immunology and oncology, sharing your expertise both within and beyond the IO Discovery group. You will also stay up to date with new technologies and assay formats for evaluation of human immune function. You will present findings in multiple group and departmental meetings. You will be expected to maintain accurate electronic records of experiments and ensure that your own work, and work of peers, follows Good Laboratory Practice, Safety, Health and Environment standards and all other relevant internal and external regulations and standards.
Essential Skills/Experience:
* Ph.D. in Immunology or related scientific subject area and 2-6 years post-doctoral and/or industry experience in immunology based role
* Strong background and experience in immunology
* Proficiency in isolating/culturing primary human immune cells (T cells, NK cells, and myeloid cells)
* Experience with primary cell functional assays such T cell/macrophage/neutrophil cell-dependent cytotoxicity experiments
* Strong understanding of T cell and myeloid biology
* Extensive experience with multi-color flow cytometry
* Experience with ELISA assays and multiplex cytokine assays
* Proficiency using Excel, GraphPad Prism, and FlowJo for data analysis
* Excellent written and oral communication skills
* Strong data management and record keeping skills
Desirable Skills/Experience:
* Experience with in vivo mouse tumor models
* Experience with biochemical assays such Western blots
* Expertise with complex, multi-cell type, functional assays
* Familiarity with industry style timeline management and proven ability to plan and deliver results accordingly
At AstraZeneca, we are united in our vision to eliminate cancer as a cause of death. Our Oncology R&D team is at the forefront of applying science to studies and using innovative approaches to create new possibilities. We take an inter-disciplinary approach including novel biomarkers, AI, novel endpoints and ground breaking trial designs to shape the future of our business and Oncology. We believe in growing together and providing a place where everyone can have a voice. We foster a mentality of courage, where everyone is empowered to step up, innovate and work at pace. Our pipeline is a testament to our growth, both now and in the future.
About Our Gaithersburg Oncology Hub
Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We are dedicated to creating a culture of inclusion and collaboration.
The Gaithersburg site offers a variety of amenities to help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center, game rooms, community garden and more. This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams.
So, what's next?
Ready to make a difference? Apply now to join our team!
If you're curious to know more, please contact Bobbi Poole, our Talent Acquisition Partner.
Closing Date: December 5, 2024
Competitive remuneration and benefits apply
We offer a competitive Total Reward program including a market driven base salary, bonus and long term incentive. We have a generous paid time off program and a comprehensive benefits package.
Where can I find out more-
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AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We follow all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.
We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
The annual base pay (or hourly rate of compensation) for this position ranges from $105,875 to $158,812. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an at-will position and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.
Date Posted
21-Nov-2024
Closing Date
04-Dec-2024Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.
AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.