Structural Biology & Biophysics Principal Research Scientist
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Structural Biology & Biophysics Principal Research Scientist page is loaded Structural Biology & Biophysics Principal Research Scientist Apply locations San Diego, CA time type Full time posted on Posted 30+ Days Ago job requisition id REQ-22914

Job Description

General Summary:

Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has approved medicines that treat the underlying causes of multiple chronic, life-shortening genetic diseases — cystic fibrosis, sickle cell disease and transfusion-dependent beta thalassemia — and continues to advance clinical and research programs in these diseases. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases.

The Principal Scientist will contribute to our research efforts in structural biology, biophysics, and biochemistry as an integral member of the Protein Sciences Department. The Department is responsible for all gene to structure work as well as cell-based approaches to study the mechanism of action of new and existing therapies. This role will be on-site in our state-of-the-art research facility in San Diego.

Key Duties and Responsibilities:

• Provide hands-on contributions to strengthen Vertex' internal capabilities in Cryo Electron Microscopy (CryoEM), Cryo Electron Tomography (CryoET), mechanism of action (MoA) studies, and structure-based new drug design.
• Provide hands-on contributions to visualize macromolecular structures at a nanoscale resolution within their natural environment.
• Implement AI-based technologies to facilitate protein construct design and protein structure determination.
• Design and perform sophisticated and technically challenging mechanism of action studies that impact critical project goals.
• Generate effective hypotheses to pursue project goals and encourage the use of new experimental approaches.
• Integrate and collaborate with different functions across the organization.

Knowledge and Skills:

• Deep understanding (industry experience preferred) in applying and developing emerging CryoEM, CryoET, and biophysical technologies to solve protein structures at atomic resolution and macromolecular assemblies within their natural environment.
• Ability to apply AI-based techniques to facilitate protein construct design and protein structure prediction.
• Experience in designing and building mechanistic assays to define mechanism of action of various therapeutic approaches.
• Experience with multiparameter optimization of sample preparation.
• Established reputation with a track record in the field of membrane protein biochemistry, biophysics, and structural biology.
• Demonstrated independent thought/creativity in science with attention to details.
• Experience in working with multi-disciplinary teams.
• Excellent communication (oral and written) in articulating goals, objectives, hypotheses, and results to the group and larger cross-functional project teams.
• Ability to navigate and be successful in a fast-paced, cross-functional, and multi-disciplinary work environment.

Education and Experience:

• Ph.D. (or equivalent degree) in cellular biology, biochemistry, biophysics, or related disciplines and 4-7 years of relevant post-doctoral employment experience, or
• Masters Degree (or equivalent degree) in cellular biology, biochemistry, biophysics, or related disciplines and 7+ years of relevant employment experience, or
• Bachelors Degree (or equivalent degree) in cellular biology, biochemistry, biophysics, or related disciplines and 10+ years of relevant employment experience

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Pay Range:

$132,000 - $198,000

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation:

On-Site Designated

Flex Eligibility Status:

In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ...@vrtx.com

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Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has approved medicines that treat the underlying causes of multiple chronic, life-shortening genetic diseases — cystic fibrosis, sickle cell disease and transfusion-dependent beta thalassemia — and continues to advance clinical and research programs in these diseases. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including APOL1-mediated kidney disease, acute and neuropathic pain, type 1 diabetes, myotonic dystrophy type 1 and alpha-1 antitrypsin deficiency .

Founded in 1989 in Cambridge, Mass., Vertex's global headquarters is now located in Boston's Innovation District and its international headquarters is in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 14 consecutive years on Science magazine's Top Employers list and one of Fortune's 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on Facebook , Twitter/X , LinkedIn , YouTube and Instagram .

The diversity and authenticity of our people is part of what makes Vertex unique, and we recognize that each employee brings diverse perspectives and strengths. By embracing those strengths and celebrating differences, we are fostering an inclusive culture where each of us can bring our authentic selves to work, inspire innovation together, and change people's lives.

Our vision is clear: to be the place where an authentic, diverse mix of talent want to come, to stay, and do their best work.

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