Location: Swiftwater,PA, USA
**Job Title:** Upstream Manager Scientist - Vaccine
**Location:** Swiftwater, PA
**About the Job**
We deliver 4.3 billion healthcare solutions to people every year, thanks to the flawless planning and meticulous eye for detail of our Manufacturing & Supply teams. With your talent and ambition, we can do even more to protect people from infectious diseases and bring hope to patients and their families. Your job, as a Upstream Manager Scientist - Vaccine within our Baculo USP Lab, will have the potential to transform the practice of medicine, turning the impossible into possible for millions of people.
We are an innovative global healthcare company that helps the world stay ahead of infectious diseases by delivering more than 500 million vaccine doses a year. Across different countries, our talented teams are exploring new technologies to protect people and promote healthy communities. We chase the miracles of science every single day, pursuing progress to make a real impact on millions of patients around the world.
**Department Description**
The Upstream Development Group, as a part of the Manufacturing Technology Department, has responsibilities to support the development and continuous improvement of bioprocesses for manufacturing of Influenza, Meningitis, COVID, and other vaccines. It encompasses the development of seeds, production processes (Batch and Fed-Batch), evaluation, and improvements of process parameters.
**Position Overview/Key Responsibilties**
Primary responsibility will be to work as a part of the working virus bank (WVB) generation group. WVB is a recombinant baculovirus seed for manufacturing drug substances for Influenza & COVID vaccines.
**Day-to-Day Responsibilities:**
**What:**
+ Maintenance of insect cells in suspension culture at different scales (shake flasks, waves, small and pilot size bioreactors)
+ Transfection of insect cells, baculovirus plaque purification, infection & scale-up of baculovirus stocks
+ Sampling cell culture and preparation of samples for analytical testing
+ Performing standard molecular biology tasks such as baculovirus DNA purification, PCR, restriction endonucleases digest, DNA agarose gel electrophoresis
+ Performing analysis of recombinant protein expression by Western blot, SDS-PAGE, and single radial immunodiffusion techniques (SRID)
+ Responsible for completing paperwork for each task
+ Maintenance of the labs and ordering of supplies
+ Communicate with co-workers and present data on a regular basis at the group and department meetings
+ Flexible in time management
+ Complies with all company policies and standard
**How** :
+ Behaves according to company values and competencies.
+ Influences internally; forward thinking with an attitude of collaboration, optimization, efficiency, continuous improvement.
+ Proactively anticipates and effectively communicates successes, constraints, conflicts, solutions and actions for resolution.
+ Proactively resolves conflicts, removes roadblocks to execution within sphere of influence; escalates to functional management when appropriate.
+ Fosters relationships with partners, experts from other functions and customers in order to achieve technical objectives.
**About you**
**Basic Qualifications**
+ Bachelor or Master in biology, cell biology, molecular biology, biochemistry, chemistry or related field.
+ Experience in microbial and molecular biology techniques and, procedures, and aseptic techniques.
+ Ability to utilize Microsoft Excel, PowerPoint and Word to perform tasks
+ Ability to plan and conduct laboratory experiments, evaluate, and interpret data.
+ Ability to work with minimum supervision.
+ Detail-oriented and ability to prioritize assignments.
+ Fluent in both written and spoken English
**Preferred Qualifications**
+ Experience in cell culture procedures and associated aseptic techniques
+ Experience in molecular biology procedures
+ Willing to work changing schedules and hours as needed
+ Able to work effectively in a collaborative team
+ Detail-oriented and able to prioritize assignments
+ Strong verbal and written communication skills.
**Why Choose Us?**
+ Bring the miracles of science to life alongside a supportive, future-focused team.
+ Discover endless opportunities to grow your talent and drive your career, whether it's through a promotion or lateral move, at home or internationally.
+ Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
+ Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks' gender-neutral parental leave.
Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.
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